Endoscopic-mediated, biliary hydrodynamic injection mediating clinically relevant levels of gene delivery in pig liver

Post written by Robert L. Kruse, MD, PhD, from the Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Viral-based approaches predominate the field of gene therapy for rare diseases but suffer many limitations including anti-vector immune responses and high cost of manufacturing. Our study focused on developing a novel nonviral …

Continue reading Endoscopic-mediated, biliary hydrodynamic injection mediating clinically relevant levels of gene delivery in pig liver

Endoscopic submucosal dissection by using a new traction device

Post written by Masami Omae, MD, from the Division of Medicine, Department of Upper Gastrointestinal Diseases, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden. We report a case of endoscopic submucosal dissection (ESD) using a new off-the-shelf traction device that is easy to deploy and enables easier access to the submucosa during ESD. Several devices …

Continue reading Endoscopic submucosal dissection by using a new traction device

Gastric neoplasms in patients with familial adenomatous polyposis: endoscopic and clinicopathologic features

Post written by Yusaku Shimamoto, MD, from the Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan. Gastric neoplasms in familial adenomatous polyposis (FAP) patients were classified into 4 types based on endoscopic findings. Then, their clinical, histopathologic, and genetic features were investigated. Gastric neoplasms in patients with FAP are endoscopically and histopathologically characteristic …

Continue reading Gastric neoplasms in patients with familial adenomatous polyposis: endoscopic and clinicopathologic features

Cost-effective modified endoscopic vacuum therapy for the treatment of gastrointestinal transmural defects

Post written by Diogo Turiani Hourneaux de Moura, MD, MSc, PhD, from the Gastrointestinal Endoscopy Unit, Gastroenterology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. We highlight a cost-effective modified endoscopic vacuum therapy (EVT) technique for the management of gastrointestinal transmural defects and demonstrate the step-by-step process …

Continue reading Cost-effective modified endoscopic vacuum therapy for the treatment of gastrointestinal transmural defects

Detection of elusive polyps using a large-scale artificial intelligence system

Post written by Dan M. Livovsky, MD, from the Faculty of Medicine, Hebrew University of Jerusalem, and the Digestive Diseases Institute, Shaare Zedek Medical Center, Jerusalem, Israel. Our study aimed to evaluate the performance of a newly developed AI-based system for polyp detection, DEEP2 (DEEP DEtection of Elusive Polyps) on the detection of elusive polyps, …

Continue reading Detection of elusive polyps using a large-scale artificial intelligence system

Successful ESD for a tumor located completely within a colonic diverticulum after inversion of the diverticulum using a traction device

Post written by Takashi Muramoto, MD, PhD, from the Department of Gastrointestinal Endoscopy, NTT Medical Center Tokyo, Tokyo, Japan. We presented endoscopic submucosal dissection (ESD) for a tumor located completely within a colonic diverticulum using a traction device in the video. The lesion was a flat-elevated tumor completely located within a colonic diverticulum in the …

Continue reading Successful ESD for a tumor located completely within a colonic diverticulum after inversion of the diverticulum using a traction device

Esophageal ESD on postendoscopic variceal ligation scars with injection under red dichromatic imaging

Post written by Kurato Miyazaki, MD, from the Division of Gastroenterology and Hepatology, Department of Internal Medicine, and the Division of Research and Development for Minimally Invasive Treatment, Cancer Center, Keio University School of Medicine, Tokyo, Japan. Red dichromatic imaging (RDI) is a recently developed novel image-enhanced endoscopy that enables one to visualize blood vessels …

Continue reading Esophageal ESD on postendoscopic variceal ligation scars with injection under red dichromatic imaging

Endoscopic ultrasound–guided liver biopsy: needle types and suction methods

Post written by Catherine Vozzo, DO, from the Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, Ohio. Endoscopic ultrasound-guided liver biopsy is gaining traction amongst the advanced endoscopy and hepatology community. It is safe and effective at delivering adequate liver biopsy specimens. In this tools and techniques article, we describe the variety of needles and …

Continue reading Endoscopic ultrasound–guided liver biopsy: needle types and suction methods

The use of the cap and underwater technique as an aid in endoscopic diagnosis and treatment of upper gastrointestinal bleeding

Post written by Fernando Lander Mota, MD, from the Department of Digestive Endoscopy, Hospital Sírio-Libanês, São Paulo, Brazil. Here we describe 4 cases where the use of cap and underwater technique was decisive in the management of gastrointestinal bleeding of different etiologies. The attachment of a simple transparent plastic cap allowed us to push aside …

Continue reading The use of the cap and underwater technique as an aid in endoscopic diagnosis and treatment of upper gastrointestinal bleeding

Usefulness of a newly designed laser-cut metal stent with an anchoring hook and thin delivery system for EUS-guided hepaticogastrostomy in experimental settings

Post written by Masayuki Kitano, MD, PhD, from the Second Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan. We developed a partially covered self-expandable metal stent with a thin delivery system (7.2 Fr) that has 2 advantages for EUS-guided hepaticogastrostomy (EUS-HGS). First, using a thin delivery system with a tapered tip, the stent can …

Continue reading Usefulness of a newly designed laser-cut metal stent with an anchoring hook and thin delivery system for EUS-guided hepaticogastrostomy in experimental settings