Pooled rates of adenoma detection by colonoscopy in asymptomatic average-risk individuals with positive fecal immunochemical test: a systematic review and meta-analysis

Post written by Babu P. Mohan, MD, from the Department of Gastroenterology & Hepatology, Department of Medicine, University of Utah Health, Salt Lake City, Utah, USA.


The focus of this study was to evaluate the pooled rates of adenoma detection in fecal immunochemical test (FIT)-positive colonoscopy.

Current adenoma detection rate (ADR) thresholds in FIT-positive colonoscopy as proposed by the U.S. Multi-Society Task Force on Colorectal Cancer are ≥35% for women and ≥45% for men. These benchmarks are based on weak evidence.

The results of this study support the current ADR benchmarks in FIT-positive colonoscopy as put forth by professional GI societies. The overall pooled ADR in FIT-positive colonoscopy was 47.8% (58.3% in men and 41.9% in women). Future data are warranted to evaluate polyp detection rates and ADRs based on polyp histology.

Excellent pooled ADR parameters were demonstrated with qualitative assessment of 1 stool sample at a test cutoff value of 100 ng hemoglobin/mL. Over a span of 20 years, our results demonstrate that the overall pooled ADR improved from 30.5% to 47.8%.


Graphical Abstract

Read the full article online.

The information presented in Endoscopedia reflects the opinions of the authors and does not represent the position of the American Society for Gastrointestinal Endoscopy (ASGE). ASGE expressly disclaims any warranties or guarantees, expressed or implied, and is not liable for damages of any kind in connection with the material, information, or procedures set forth.

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