Endoscopic detection rate of sessile serrated lesions in Lynch syndrome patients

Vleugels_headshotPost written by Jasper L.A. Vleugels, MD, from the Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

We compared endoscopic detection rates and distribution of sessile serrated lesions in Lynch syndrome patients to a matched control population in this case-control study.

Cancers in Lynch syndrome are generally assumed to go through the conventional adenoma-to-carcinoma development sequence, but there has been speculation as to whether the serrated neoplasia pathway plays a role. To investigate this hypothesis, we retrospectively examined results from colonoscopies and removed polyps were reviewed by specialist pathologists who were blinded to the initial diagnosis.

Endoscopic detection rates and distribution of sessile serrated lesions were compared in individuals with Lynch syndrome (n = 223) and matched controls (n = 223). In all, 7.6% of colonoscopies performed in Lynch patients and 6.7% in controls turned up sessile serrated lesions (P = 0.86), comparable rates. Moreover, none of the sessile serrated lesions were detected with any dysplasia in this high-risk population. Hence, we concluded that the function of the serrated neoplasia pathway in terms of colorectal cancer development appears to be comparable between people with Lynch syndrome and the general population. Future studies should molecularly evaluate colorectal cancers in Lynch syndrome to determine to what extent these can be attributed to the serrated neoplasia pathway.


Read the full article online.

The information presented in Endoscopedia reflects the opinions of the authors and does not represent the position of the American Society for Gastrointestinal Endoscopy (ASGE). ASGE expressly disclaims any warranties or guarantees, expressed or implied, and is not liable for damages of any kind in connection with the material, information, or procedures set forth.

One thought on “Endoscopic detection rate of sessile serrated lesions in Lynch syndrome patients

  1. I was diagnosed with Lynch Syndrome (and a mutated ATM gene) five years ago. My dr did the test considering my family health hystory of various cancers. Ive since had to have a complete hysterectomy and other health issues. What is scary to me is when I meet with a specialist 99 percent of the time they ask ME what Lynch is. Im glad to know that researchers are continuing to study this disease. Maybe they cant cure it, but the diagnosis was the only reason my dr did an complete exam and found a large tumor spreading in my uterous. I wasnt scheduled for an annual for 10 motnh. Had they not looked, I may have never made it.

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