Risk of progression in Barrett’s esophagus indefinite for dysplasia

Post written by Rajesh Krishnamoorthi, MD, from the Digestive Diseases Institute, Virginia Mason Medical Center, Seattle, Washington, USA. The current study is systematic review and meta-analysis to estimate the risk of progression to high-grade dysplasia and/or esophageal adenocarcinoma in patients with Barrett's esophagus indefinite for dysplasia. Barrett’s esophagus (BE) is a precursor lesion for esophageal …

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Increasing prevalence of high-grade dysplasia and adenocarcinoma on index endoscopy in Barrett’s esophagus

Post written by Madhav Desai, MD, MPH, from the Gastroenterology and Hepatology, University of Kansas Medical Center, Kansas City, Kansas, USA. Barrett’s esophagus (BE) is a known precursor lesion for esophageal adenocarcinoma (EAC), and we know that incidence of the latter is rising in last 30 years thereby necessitating early detection and management of this …

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HMGA2 protein as a biomarker of dysplasia in IPMN

Christopher J. DiMaio, MD, FASGE, from the Icahn School of Medicine at Mount Sinai, Mount Sinai Medical Center, in New York, New York, USA discusses his article "Pancreatic cyst fluid concentration of high-mobility group A2 protein acts as a differential biomarker of dysplasia in intraductal papillary mucinous neoplasm." No reliable cyst fluid biomarkers exist that …

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Salvage cryotherapy after failed radiofrequency ablation

Neil Sengupta, MD, from the Department of Medicine and Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, in Boston, Massachusetts, USA describes this Original Article, "Salvage cryotherapy after failed radiofrequency ablation for Barrett’s esophagus–related dysplasia is safe and effective." Radiofrequency ablation (RFA) is an effective and durable treatment option for patients with …

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Editor’s Choice- Consensus statement on dysplasia in IBD

Associate Editor Dr. Seth Gross highlights this article “SCENIC international consensus statement on surveillance and management of dysplasia in inflammatory bowel disease” by Loren Laine, MD, Tonya Kaltenbach, MD, Alan Barkun, MD, Kenneth R. McQuaid, MD, Venkataraman Subramanian, MD, and Roy Soetikno, MD for the SCENIC Guideline Development Panel as March’s Editor’s Choice. The article …

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Editor’s Choice: Detection and staging of esophageal cancers within BE

Associate Editor Jacques Devière, MD, PhD recommends this Original Article from the December issue "Detection and staging of esophageal cancers within Barrett’s esophagus is improved by assessment in specialized Barrett’s units." The authors clearly address a common problem in the assessment of patients having Barrett's esophagus (BE) and dysplasia. In 2014, evaluation of these patients includes …

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Sessile serrated adenomas/polyps with cytologic dysplasia

Authors Dr. Nicholas Burgess and Dr. Michael Bourke from Westmead Hospital and the University of Sydney in Sydney, NSW, Australia discuss their Thinking Outside the Box article "Sessile serrated adenomas/polyps with cytologic dysplasia: a triple threat for interval cancer" from the August issue. Sessile serrated adenoma/polyps (SSA/P) are now recognized to play an important role …

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