Editor’s Choice: The safety and efficacy of 2% vitamin C solution spray for relief of mucosal irritation caused by Lugol chromoendoscopy


GIE Associate Editor, Dr. Fauze Maluf-Filho, highlights this article from the September issue “The safety and efficacy of 2% vitamin C solution spray for relief of mucosal irritation caused by Lugol chromoendoscopy” by Duochen Jin, PhD, et al. 

Lugol chromoendoscopy is necessary for the identification of superficial esophageal squamous cell carcinoma. Lugol solution is alcoholic, causing mucosal irritation and, consequently, symptoms such as thoracic pain and heartburn. The use of an antidote to mitigate those symptoms is an integral part of Lugol chromoendoscopy. The 5% sodium thiosulfate solution is the antidote to Lugol. In this study, the authors tested a novel antidote to Lugol, a 2% vitamin C solution.

In a randomized, non-inferiority trial, the authors demonstrated that vitamin C is noninferior to thiosulfate to mitigate Lugol chromoendoscopy-related symptoms.

When employing Lugol chromoendoscopy of the esophagus, the use of an antidote is necessary to mitigate Lugol-related mucosal irritation and symptoms. A 2% vitamin C solution is a novel antidote that can be safely and effectively used in this context.

Read the article abstract here.

The information presented in Endoscopedia reflects the opinions of the authors and does not represent the position of the American Society for Gastrointestinal Endoscopy (ASGE). ASGE expressly disclaims any warranties or guarantees, expressed or implied, and is not liable for damages of any kind in connection with the material, information, or procedures set forth.

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