Potential for peritoneal cancer cell seeding in endoscopic full-thickness resection

Goto_headshotPost written by Osamu Goto, MD, PhD, from the Division of Research and Development for Minimally Invasive Treatment, Cancer Center, Keio University, School of Medicine, Tokyo, Japan.

This article is focusing on the importance of non-exposure technique in local resection for early gastric cancers. We prospectively investigated the ability of cancer cells to be detached by touching the tumor surface, to assess the possibility of transplantation due to contact with tumor cells by exposure technique.

It is controversial whether cancer cells can be translocated from the stomach to the abdominal space in an opening technique of gastrectomy, not by spilling the gastric juice but by touching exposed cancer cells with surgical instruments.

In early gastric cancers resected by endoscopic submucosal dissection, stamp cytology was performed by touching the surface of the specimens to glass slides. We demonstrated that cancer cells, including cancer stem cells, were easily detached via contact with the tumor surface. Therefore, in local resection including endoscopic full-thickness resection, a non-exposure approach should be recommended to avoid the risk of iatrogenic cancer cell seeding via contact with and transplantation of cancer cells. It would be desirable to investigate the ability of detached cancer cells to survive and grow in vitro as the next step.


Some non-exposed endoscopic full-thickness resection techniques with or without laparoscopic assistance have been introduced. These techniques would be promising as minimally-invasive surgery for cancers or ulcerated submucosal tumors.

Read the full article online.

The information presented in Endoscopedia reflects the opinions of the authors and does not represent the position of the American Society for Gastrointestinal Endoscopy (ASGE). ASGE expressly disclaims any warranties or guarantees, expressed or implied, and is not liable for damages of any kind in connection with the material, information, or procedures set forth.

Leave a Comment

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s