Yousuke Nakai, MD, PhD, from the Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, in Tokyo, Japan discusses this New Methods article, “A pilot study of EUS-guided through-the-needle forceps biopsy (with video).”
In this pilot study, we evaluated EUS-guided through-the-needle forceps biopsy (EUS-TTNFB), using a 0.75-mm biopsy forceps through a 19-gauge FNA needle.
Advances in next-generation sequencing for personalized medicine have increased the demand for core tissue, and EUS-TTNFB enables the acquisition of additional “core” during EUS-FNA procedures. In addition, recent development of miniature devices enables various through-the-needle procedures such as cystoscopy, confocal laser endomicroscopy, portal vein pressure measurement and photodynamic therapy. This study adds to this growing variety of through-the-needle procedures.
Figure 1. Miniature biopsy forceps going through a 19-gauge needle.
A total of 49 passes of EUS-TTNFB were performed in 17 cases and were technically successful in 100%. Macroscopic histologic core was obtained in 71% per pass by EUS-TTNFB and with a single pass of a 19-gaguge FNA needle the tissue acquisition rate was 89%. Of note, EUS-TTNFB provided a histologic specimen in 5 of 14 passes when subsequent EUS-FNA failed to obtain a histologic specimen.
Find the article abstract here.
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