Post written by Wai Keung Leung, MD, from the Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China.

This study aimed to determine long-term colonoscopy outcomes in patients after computer-assisted detection (CADe) colonoscopy at baseline.

Although CADe colonoscopy has been consistently demonstrated to increase the colorectal adenoma or polyp detection rate, the role of CADe colonoscopy in reducing the risk of metachronous lesions remains unproven.

In a propensity score matching analysis comparing surveillance colonoscopy findings of 162 patients with baseline use of CADe or conventional colonoscopy, the use of CADe was associated with a lower rate of advanced adenoma detection (11.1% vs 24.1%; P = .05) and the number of advanced adenomas detected per colonoscopy (0.1 vs 0.3; P = .01).

A similar trend was observed for the adenoma detection rate (44.4% vs 63.0%; P = .02) and the number of adenomas detected per colonoscopy (0.6 vs 1.2; P = .01). The cumulative incidence of patients with any metachronous adenoma or serrated lesion also was significantly lower in those with baseline use of CADe than those with conventional colonoscopy (log rank P = .05).

Further large-scale prospective studies are needed to verify the role of CADe in reducing the risk of metachronous colorectal lesions.

Cumulative incidence of metachronous adenomas or serrated lesions detected for the PSM cohort. CADe, Computer-assisted detection; PSM, propensity score matching.

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