Post written by Maria Valeria Matteo, MD, from Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

This study is a prospective, multicenter, international, observational postmarket registry aimed at assessing the safety and efficacy of the Endomina triangulation platform (Endo Tools Therapeutics, Gosselies, Belgium) for endoscopic gastroplasty in treating obesity. It specifically evaluates the technique’s real-world application, focusing on weight loss outcomes, improvements in quality of life, and potential adverse events.

The global prevalence of obesity continues to rise, with a significant need for effective and safe therapeutic options. Traditional bariatric surgeries, although effective, are performed in only a small percentage of eligible patients because of concerns about morbidity, mortality, and limited resources. Endoscopic gastroplasty provides a less-invasive alternative that could address these barriers while delivering significant therapeutic benefits. This study was essential in validating the real-world safety and efficacy of the Endomina platform for endoscopic gastroplasty, aiming to bridge the gap between medical and surgical treatments.

This study presents real-world evidence that endoscopic gastroplasty with Endomina is safe and effective for treating obesity. Among the 142 patients treated, no serious device-related adverse effects or severe procedure-related events were reported.

At 12-month follow-up, the patients experienced a mean total body weight loss of 15.3% and a mean excess weight loss of 48.5%. In addition, improvements in quality of life were noted, as measured by EuroQol 5 Dimension and Bariatric Analysis and Reporting Outcome System scores. These findings are consistent with those of previous studies, highlighting the technique’s effectiveness and durability while encouraging implementation of this technique in routine clinical practice, even outside academic settings.

This study addresses a critical need for accessible, less-invasive weight loss interventions. Although limitations such as short-term follow-up and modest sample size exist, the findings pave the way for broader adoption and further research into endoscopic gastroplasty with Endomina as a viable alternative to traditional bariatric surgery.

Endomina triangulation platform: A, overview. B, Endomina assembled with the endoscope and bent (90°) channel.

Read the full article online.

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