Post written by Kenichiro Okimoto, MD, PhD, from the Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Prophylactic clipping may be unnecessary to prevent delayed bleeding (DB) after colorectal cold snare polypectomy (CSP) in patients on antithrombotic agents.

There is no consensus on the effectiveness of prophylactic clipping after colonic CSP. This study aimed to evaluate the use of prophylactic clipping in preventing DB after colorectal CSP in patients on antithrombotic agents.

The study included 133 patients (422 polyps) requiring prophylactic clipping and 85 patients (282 polyps) not requiring prophylactic clipping. DB and hematochezia rates had no significant difference between the groups. By weighted logistic regression analysis, the odds ratio of hematochezia was 0.557 (95% confidence interval, 0.225-1.378; P = .205) in patients without clipping compared with those with clipping.

Multicenter randomized controlled trials, including a study at our institution, are underway to investigate prophylactic clip hemorrhage control for colorectal CSP in patients taking antithrombotic drugs.

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