Why did the sham-treated EPISOD study subjects do so well?

Post written by Peter B. Cotton, MD, FRCS, FRCP, from the Digestive Disease Center, Medical University of South Carolina, Charleston, South Carolina, USA. The EPISOD study showed that sphincterotomy was not helpful for patients with post-cholecystectomy pain and little or no evidence for biliary obstruction (“SOD type III”). The conclusion was surprising; especially to those …

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