Post written by Sergio Cadoni from the Digestive Endoscopy Unit at St. Barbara Hospital in Iglesias, Italy. Water exchange (WE) is the least painful insertion method during colonoscopy. However, its impact on postcolonoscopy discomfort has not been well-described. Carbon dioxide (CO2) insufflation has been consistently shown to decrease postcolonoscopy discomfort. We compared postcolonoscopy outcomes of various combinations …