Post written by Nobuhisa Minakata, MD, PhD, and Tomonori Yano, MD, PhD, from the Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan.

We present the case of a patient who achieved local control with endoscopic combination therapy using photodynamic therapy and endoscopic resection for wide-circumferential local recurrence after radiotherapy for esophageal squamous cell carcinoma.

In cases of wide-circumferential local recurrence, surgery is generally considered, but in cases where patients are intolerant to or refuse surgery, palliative treatments such as best supportive care and chemotherapy have been performed. To our knowledge, this is the first case report on endoscopic curative treatment for wide-circumferential local recurrence.

Our video case serves as an invaluable reference and start for implementation in clinical practice.

Our hope is to raise awareness that this endoscopic combination therapy is a minimally invasive and potentially curative option for patients with wide-circumferential local recurrence.

Key images of the case report. A, The local residual lesion after radiotherapy. B, At 1 day after initial PDT. C, Nontreated lesions around the laser-illuminated area (yellow arrowheads). D, Lesions were resected using hybrid endoscopic submucosal dissection. E, No recurrence 1 year after the second additional PDT. PDT, Photodynamic therapy.

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